Ka anyị mụta ihe gbasara nlekọta anụ ahụ ọnụ -Ergothioneine

Ergothionein (mercapto histidine trimethyl esịtidem nnu)

Ergothionine(EGT) bụ antioxidant eke nwere ike ichebe mkpụrụ ndụ n'ime ahụ mmadụ yana ihe dị mkpa na-arụ ọrụ n'ime ahụ.

Na ngalaba nlekọta anụ ahụ, ergotamine nwere mmetụta antioxidant dị ike. Ọ nwere ike wepụ radicals free, belata mmebi oxidative, chebe mkpụrụ ndụ akpụkpọ ahụ site na ihe gburugburu ebe obibi dịpụrụ adịpụ, nyere aka igbu oge ịka nká, ma nọgide na-agbatị akpụkpọ ahụ na nchapụta.

Na mgbakwunye na ngalaba nlekọta anụ ahụ, ergotamine nwekwara ngwa na ụlọ ọrụ ọgwụ. Dịka ọmụmaatụ, na mmepe nke ọgwụ ụfọdụ, enwere ike iji ya dị ka ihe enyemaka iji nyere aka kwalite nkwụsi ike na ịdị irè nke ọgwụ ahụ. N'ihe gbasara nri, enwekwara ọmụmụ ihe na-enyocha ohere nke iji ya dị ka ihe mgbakwunye nri iji kwalite njirimara antioxidant nke nri na ịgbatị ndụ ya.

Ergothionein nwere nchekwa dị elu. Na ngwaahịa nlekọta anụ ahụ, ntinye nke ihe mgbakwunye na-adịkarị iche dabere na usoro na arụmọrụ achọrọ nke ngwaahịa, n'ozuzu sitere na 0.1% ruo 5%.

Ọrụ dị mkpa
Antioxidant

Ergothionein nwere ike meghachi omume ngwa ngwa na radicals efu iji mee ka ha ghọọ ihe na-adịghị emerụ ahụ, ọ naghịkwa efu ya ngwa ngwa. N'otu oge ahụ, ọ nwere ike idowe ọkwa nke antioxidants ndị ọzọ (dịkaVC na glutathione), si otú a na-echebe mkpụrụ ndụ akpụkpọ ahụ site na mmebi oxidative.

Usoro ya bụ iji mebie nke ọma - OH (hydroxyl radicals), chelate divalent iron ion na ọla kọpa, gbochie H2O2 imepụta - OH n'okpuru ọrụ nke ígwè ma ọ bụ ọla kọpa, na-egbochi ion ọla kọpa oxidation nke hemoglobin oxygenated, yana igbochi mmeghachi omume peroxidation nke na-akwalite arachidonic acid mgbe myoglobin (ma ọ bụ hemoglobin) jikọtara ya na H2O2.

mgbochi mkpali
Nzaghachi mkpali dị n'ime ahụ bụ nzaghachi ebumpụta ụwa na-agbachiterekarị maka mkpali, yana ngosipụta nke nguzogide ahụ megide ihe ndị na-emebi emebi. Ergothionein nwere ike igbochi mmepụta nke ihe ndị na-egbuke egbuke, belata ogo nke mmeghachi omume mkpali, ma belata ahụ erughị ala akpụkpọ ahụ. Ọ na-egosipụta mmetụta mgbochi mkpali site n'ịhazi ụzọ mgbaàmà intracellular na igbochi okwu nke mkpụrụ ndụ ihe nketa metụtara mbufụt. Dịka ọmụmaatụ, maka akpụkpọ anụ dị nro ma ọ bụ ihe otutu, ergotamine nwere ike inye aka belata mbufụt ma kwalite nrụzi akpụkpọ ahụ.

Na-egbochi ịse foto
Ergothionein nwere ike igbochi nbibi DNA nke ìhè ultraviolet na hydrogen peroxide kpatara, ma nwee ike ịbọ ọbọ na radicals free ma nweta radieshon ultraviolet iji kpochapụ mmebi DNA. N'ime oke mmịpụta nke ultraviolet, ergothionein nwere ogologo ogologo mmịpụta dịka nke DNA. Ya mere, ergothionein nwere ike ije ozi dị ka ihe nzacha physiological maka radieshon ultraviolet.

Ugbu a, ọtụtụ nchọpụta egosila na ergotamine bụ ihe na-eme ka anwụ na-acha ọkụ na-arụ ọrụ nke ọma nke nwere ike igbochi mmebi akpụkpọ ahụ site na radieshon UV.
Kwalite ọgbọ nke protein collagen
Ergothionein nwere ike ịkwalite mmụba nke ọnụ ọgụgụ fibroblasts ma kpalie njikọ nke collagen na elastin. Ọ na-akwalite nkwupụta nke mkpụrụ ndụ ihe nketa collagen na njikọ protein site n'ịgbalite ụfọdụ mkpụrụ ndụ ihe mgbaàmà n'ime sel.