N'ụwa nke nlekọta anụ ahụ, niacinamide dị ka onye na-eme egwuregwu gburugburu, na-emeri obi nke ọtụtụ ndị hụrụ ịma mma n'anya site na ọtụtụ mmetụta ya. Taa, ka anyị kpughee ihe omimi dị omimi nke “kpakpando nlekọta anụ ahụ” a wee nyochaa ihe omimi sayensị ya yana ngwa bara uru ọnụ.
1. Nchọpụta sayensị nke nicotinamide
Niacinamidebụ ụdị vitamin B3, nke a maara nke ọma dị ka pyridine-3-carboxamide. Ọdịdị molekụla ya nwere mgbanaka pyridine na otu amide, nke na-enye ya ezigbo nkwụsi ike na ọrụ ndu.
Usoro a na-eme n'ime akpụkpọ ahụ gụnyere igbochi mbufe melanin, ịkwalite ọrụ mgbochi akpụkpọ ahụ, na ịhazi mmepụta sebum. Nnyocha egosila na nicotinamide nwere ike ịbawanye njikọ nke ceramides na fatty acids, na-eme ka iguzosi ike n'ezi ihe nke stratum corneum dịkwuo elu.
Bioavailability bụ isi ihe na-arụ ọrụ nke nicotinamide. O nwere obere ihe dị arọ (122.12 g/mol), mmiri siri ike solubility, ma nwee ike ịbanye n'ime ime epidermis nke ọma. Data nnwale na-egosi na bioavailability nke nicotinamide n'elu nwere ike iru karịa 60%.
2. Mmetụta dị iche iche nke nicotinamide
N'ihe gbasara ịcha ọcha, nicotinamide na-enweta otu ụda akpụkpọ ahụ site na igbochi nnyefe nke melanosomes na keratinocytes. Nnwale ụlọọgwụ egosila na mgbe ejiri ngwaahịa nwere 5% niacinamide maka izu asatọ, mpaghara pigmentation belatara site na 35%.
Maka njikwa mmanụ na iwepụ ihe otutu, niacinamide nwere ike ịhazi ọrụ gland sebaceous ma belata nsị sebum. Nnyocha egosila na mgbe ejiri ngwaahịa nwere 2% niacinamide maka izu anọ, secretion sebum na-ebelata site na 25% na ọnụ ọgụgụ nke pimples na-ebelata site na 40%.
N'ihe gbasara mgbochi ịka nká, niacinamide nwere ike ịkpalite njikọ collagen ma melite ngbanwe akpụkpọ ahụ. Nnwale egosila na iji ngwaahịa nwere 5% niacinamide maka izu iri na abụọ na-ebelata ahịrị dị mma akpụkpọ ahụ site na 20% ma na-abawanye nkwụ site na 30%.
Imezi ọrụ mgbochi bụ uru ọzọ dị na niacinamide. Ọ nwere ike ịkwalite njikọ nke ceramides ma mee ka akpụkpọ ahụ nwee ike ijide mmiri. Mgbe iji ngwaahịa nwere 5% niacinamide ruo izu 2, mfu mmiri transdermal nke akpụkpọ ahụ belatara site na 40%.
3. Ngwa bara uru nke nicotinamide
Mgbe ị na-ahọrọ ngwaahịa nwere niacinamide, ekwesịrị itinye uche na ntinye uche na usoro. 2% -5% bụ ebe nchekwa dị mma ma dịkwa mma, na oke itinye uche nwere ike ịkpasu iwe. A na-atụ aro ka ịmalite na obere mkpokọta ma jiri nwayọọ nwayọọ guzobe ndidi.
Atụmatụ ojiji gụnyere: iji n'ụtụtụ na mgbede, ijikọ na antioxidants (dị ka vitamin C), na ịṅa ntị na nchebe anyanwụ. Nnyocha egosiwo na nchikota niacinamide na vitamin C nwere ike ịmepụta mmetụta synergistic.
Akpachara anya: Enwere ike iwe iwe n'oge ojiji mbụ, a na-atụ aro ka ị buru ụzọ mee nnwale mpaghara. Zere iji ngwaahịa nwere oke acidity iji belata nkwụsi ike nke niacinamide.
Nchọpụta na ntinye nke nicotinamide ewetala ọganihu mgbanwe na ngalaba nlekọta anụ ahụ. Site na ịcha ọcha na ntụpọ ntụpọ na njikwa mmanụ na mgbochi ihe otutu, site na mgbochi ịka nká ruo nrụzi mgbochi, ihe ndị a na-arụ ọrụ dị iche iche na-agbanwe otú anyị si elekọta akpụkpọ ahụ anyị. Site na nghọta sayensị na iji ya eme ihe nke ọma, anyị nwere ike iji niacinamide arụ ọrụ nke ọma iji nweta anụ ahụ dị mma ma mara mma. Ka anyị gaa n'ihu na-enyocha ihe omimi nke nlekọta anụ ahụ ma na-aga n'ihu n'ụzọ nke ịchụso ịma mma.
Oge nzipu: Mar-19-2025
