Sodium hyaluronatea na-ahụ n'ọtụtụ ebe na anụmanụ na ụmụ mmadụ na-arụ ọrụ physiologically, na akpụkpọ ahụ mmadụ, mmiri synovial, eriri eriri afọ, ihe ọchị, na ophthalmic vitreous ahụ na-ekesa. Ibu molekụla ya bụ 500 000-730 000 Dalton. Ihe ngwọta ya nwere nnukwu viscoelasticity na profaịlụ. Ọ bụ adjuvant maka ịwa ahụ ophthalmic. Ọ na-edobe ụfọdụ omimi nke ime ụlọ mgbe ịgbanye n'ime ụlọ ihu. Ọ dị mma maka ịrụ ọrụ. Ọ na-echebekwa mkpụrụ ndụ endothelial corneal na anụ ahụ intraocular, na-ebelata nsogbu ịwa ahụ, ma na-akwalite ọgwụgwọ ọnya.
Isi iyi nke sodium hyaluronate
Sodium hyaluronatebụ polysaccharide macromolecule ewepụtara na ahụ vitreous bovine. Ọ nwere njirimara atọ: mgbochi ịka nká na nkwakọ ngwaahịa ọhụrụ na ịnakwere biotechnology.
Sodium hyaluronate bụ otu n'ime ihe mejupụtara akpụkpọ ahụ mmadụ, bụ mucosa acid a na-ekesa n'ime ahụ, dị na matrix nke anụ ahụ njikọ, ma nwee mmetụta dị nro.
Njirimara nke sodium hyaluronate
Sodium hyaluronate nwere njirimara atọ: mgbochi ịka nká na nkwakọ ngwaahịa ọhụrụ na teknụzụ biotechnology. Sodium hyaluronate bụ otu n'ime ihe ndị dị na akpụkpọ ahụ mmadụ na mucose acidic na-ekesa na ahụ mmadụ. Ọ dị na matriks nke anụ ahụ njikọ ma nwee mmetụta dị mma nke mmiri mmiri.
Uru nke sodium hyaluronate
1. Imelite Pharmacodynamics
Hyaluronic acidbụ isi akụkụ nke njikọ anụ ahụ dị ka interstitium mmadụ, ahụ vitreous, na mmiri synovial. Ọ nwere njirimara nke idobe mmiri, idowe oghere extracellular, na-achịkwa nrụgide osmotic, mmanye mmanụ, na ịkwalite nrụzi cell na vivo. Dị ka onye na-ebu ọgwụ ophthalmic, ọ nwere ike ịgbatị oge njide ọgwụ n'elu anya site n'ịbawanye viscosity nke anya mmiri, meziwanye bioavailability nke ọgwụ ọjọọ, na ibelata iwe ọgwụ na anya.
Enwere ike ịgbanye ọgwụgwọ adjuvant ozugbo n'ime oghere articular dị ka mmanu maka ọgwụgwọ ọrịa ogbu na nkwonkwo, dị ka ntụtụ SPIT.
2. Crease Nguzogide
Ọkwa mmiri nke akpụkpọ ahụ nwere njikọ chiri anya na ọdịnaya nke hyaluronic acid. Site na mmụba nke afọ, ọdịnaya nke hyaluronic acid na akpụkpọ ahụ na-ebelata, nke na-ebelata ọrụ idebe mmiri nke akpụkpọ ahụ ma na-emepụta wrinkles. Sodium hyaluronate aqueous ngwọta nwere ike viscoelasticity na mmanu mmanu. Mgbe etinyere ya n'elu akpụkpọ ahụ, ọ nwere ike ịmepụta ihe nkiri na-eme ka mmiri na-eme ka akpụkpọ ahụ dị mmiri ma na-egbuke egbuke. Obere molekul hyaluronic acid nwere ike banye n'ime dermis, na-akwalite microcirculation ọbara, na-enyere akpụkpọ ahụ aka ịmịkọrọ nri, ma rụọ ọrụ ịchọ mma na mgbochi mgbochi.
3. Mmetụta moisturize
Mmetụta moisturizing bụ ọrụ kachasị mkpa nkesodium hyaluronate na ịchọ mma. E jiri ya tụnyere ihe ndị ọzọ na-ekpo ọkụ, iru mmiri dị n'akụkụ gburugburu ebe obibi na-enwe mmetụta dị nta na mmetụta moisturize ya. Nke a pụrụ iche ọdịdị na-emegharị ka akpụkpọ dị iche iche a kara aka, dị iche iche gburugburu ebe obibi iru mmiri, dị ka akọrọ oyi na mmiri okpomọkụ, na chọrọ ịchọ mma moisturizing mmetụta. Njide mmiri nke sodium hyaluronate metụtara oke ya na ịdị arọ ya.
4. Mmetụta na-edozi ahụ
Sodium hyaluronate bụ ihe na-emepụta ihe dị ndụ na akpụkpọ ahụ, na exogenous sodium hyaluronate bụ ihe mgbakwunye na sodium hyaluronate endogenous na akpụkpọ ahụ. Sodium hyaluronate na obere àgwà nwere ike banye n'ime akpụkpọ epidermis, na-akwalite ọkọnọ nke anụ ahụ na-edozi ahụ na mkpofu nsị, si otú a na-egbochi akpụkpọ ịka nká, na-ekere òkè na cosmetology na ịma mma. Nlekọta akpụkpọ anụ dị mkpa karịa ihe ịchọ mma ndị ọzọ ma ghọọ ọchịchọ nke oge a iji nọgide na-eche ihu.
5. Mmezi na mgbochi nke mmebi akpụkpọ ahụ
A na-eji ìhè anyanwụ na-agba ma ọ bụ gbaa akpụkpọ ahụ ọkụ, dị ka reddening, blackening, peeling, etc., karịsịa site na ụzarị ultraviolet na ìhè anyanwụ. Sodium hyaluronate nwere ike ịkwalite mmụba nke akpụkpọ ahụ merụrụ ahụ site n'ịkwalite mmụba na ọdịiche nke mkpụrụ ndụ epidermal na ikpochapụ radicals na-enweghị oxygen. Tupu iji ya nwekwara mmetụta mgbochi. Usoro ya dị iche na nke na-amịkọrọ ultraviolet nke a na-ejikarị na mkpuchi anwụ. Ya mere, hyaluronic acid na ultraviolet absorbent na sunscreen ngwaahịa nlekọta anụ ahụ nwere mmetụta synergistic, nke nwere ike ibelata nnyefe nke ụzarị ultraviolet ma mezie mmebi akpụkpọ ahụ nke obere ọnụọgụ ultraviolet kpatara, si otú a na-arụ ọrụ nchebe abụọ.
Nchikota sodium hyaluronate na EGF (epidermal growth factor) nwere ike mee ka mmụgharị nke mkpụrụ ndụ epidermal dịkwuo elu ma mee ka akpụkpọ ahụ dị nro, dị nro na nke na-agbanwe. Mgbe akpụkpọ ahụ na-ata ahụhụ site na ọkụ na ọkụ dị nro, itinye ihe ịchọ mma mmiri nke nwere sodium hyaluronate n'elu nwere ike ibelata ihe mgbu ma mee ngwa ngwa ọgwụgwọ nke akpụkpọ ahụ merụrụ ahụ.
6. Lubrication na nhazi ihe nkiri
Sodium hyaluronate bụ ụdị polymer nwere mmanu siri ike na ihe na-emepụta ihe nkiri. Ngwaahịa nlekọta anụ ahụ nwere sodium hyaluronate nwere mmanu doro anya na mmetụta aka dị mma mgbe etinyere ya. Mgbe etinyere ya na akpụkpọ ahụ, enwere ike ịmepụta ihe nkiri n'elu akpụkpọ ahụ, nke na-eme ka akpụkpọ ahụ dị nro na mmiri mmiri, na-echebekwa akpụkpọ ahụ. Ngwakọta ntutu isi nke nwere sodium hyaluronate nwere ike ịmepụta ihe nkiri n'elu ntutu isi, nke nwere ike ime ka mmiri na-egbuke egbuke, mee ka mmanu mmanu, chebe ntutu isi, wepụ ọkụ eletrik na-adịghị agbanwe agbanwe, ma mee ka ntutu dị mfe ịkpụ, mara mma, na eke.
7. Ịba ụba
Sodium hyaluronate nwere nnukwu viscosity na ngwọta mmiri. Ọ nwere ike ịrụ ọrụ nke ndina na nkwụsi ike na ihe ịchọ mma.
8. Mmetụta ọgwụ ọgwụ nke Sodium Hyaluronate
Ihe na-arụ ọrụ physiological na-adị n'ọtụtụ ebe na anụmanụ na ụmụ mmadụ ma na-ekesa na akpụkpọ ahụ mmadụ, mmiri mmiri nke nkwonkwo, eriri afọ, ọchị ọchị, na ahụ anya vitreous. Ibu molekụla bụ 500000-730000 Dalton. Ihe ngwọta ya nwere nnukwu viscoelasticity na nṅomi. Ọ bụ adjuvant maka ịwa ahụ ophthalmic. Ọ na-edobe ụfọdụ omimi nke ime ụlọ mgbe ịgbanye n'ime ụlọ dị n'ihu, nke dị mma maka ịrụ ọrụ. Ọ na-echekwa mkpụrụ ndụ endothelial corneal na anụ ahụ intraocular, na-ebelata nsogbu, ma na-akwalite ọgwụgwọ ọnya.
Oge nzipu: Ọgọst-23-2023
